• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The compounds of formula I <IMAGE> wherein R is a group <IMAGE> wherein A is C2-5 alkylene, X is a bond, oxygen or sulfur, R3 is hydrogen, hydroxy, C1-4 alkoxy, halogen of atomic number of from 9 to 35, cyano, carbamoyl or a group NHCORd, wherein Rd is C1-4 alkyl, and R4 is hydrogen and, when R3 is C1-4 alkoxy, R4 additionally may be C1-4 alkoxy or, when R3 is halogen of atomic number of from 9 to 35, R4 additionally may be halogen of atomic number of from 9 to 35 either i) R1 is hydrogen or methyl and R2 is cyano, CONRaRb, COORc or CH2ORe, wherein Ra, Rb, Rc and Re independently are hydrogen or C1-4 alkyl, or ii) either R1 is methyl and R2 is Cl or Br or R1 is Cl or Br and R2 is hydrogen or methyl, with the provisos that a) X is separated from the nitrogen atom of the 3-amino-2-hydroxy-propoxy chain by at least 2 carbon atoms, b) when X is a bond, P3 is other than hydrogen and c) when R2 is cyano, R additionally may be C3-7 alkyl are useful as alpha - and beta -adrenoceptor blocking, anti-arrhythmic and anti- hypertensive agents and as inhibitors of metabolic effects of emotional stress.
    公开号:SU843740A3
    申请号:SU782639449
    申请日:1978-07-19
    公开日:1981-06-30
    发明作者:Бертольд Рихард
    申请人:Сандос Аг. (Фирма)；
    IPC主号:
    专利说明:

    (54) A METHOD FOR OBTAINING INDODOL DERIVATIVES OR SALTS Where R, and R have the indicated values and R is a group that, when reacting with the amine, produces a 2-amino-1-hydroxyethyl group, for example, the —CHu —CH or the reactive group 0 /. The derivative of this group is reacted with an amine of the general formula (iri) where R has the above meaning. Compounds according to formula (1) can be in free form or in the form of salts, addition of acids. From a compound, a scientific research institute according to formula (I) in free form can be obtained by known methods using salts with acids, for example, bis (basic) - fumarate, hydrognyalonate or hydrogenmaleate, or if R represents an oxy group, and R. denotes hydrogen, salts with strong bases, for example, with caustic sodium and vice versa. In the compounds of formula I, the carbon atom of the side chain, hydroxypropoxy, which carries an oxy group, is substituted asymmetrically, for this reason they can be in the form of racemates or optically active compounds. Of the compounds of formula 1 in optically active form, preferably those in which the (S) configuration of the side chain of hydrosypropoxy at the asymmetrically substituted carbon atom occurs. The enantiomers of the compounds of formula (I) can be obtained by known methods, for example, by cleaving with optically active acids or by carrying out the treatment according to the present invention, starting from the corresponding optically active starting materials. In the following examples, temperature indications are given in degrees Celsius. Example 1. 1- (3-chloro-2-methylindol-4-yloxy) -3- (2-phenoxyethylamine "o) -2-propanol 5 g H-chloro-4- (2,3-epoxypropoxy -2-methylindole ; 4.3 g Phenoxy ethyl and 75 ml of dioxane is heated for 15 hours in an autoclave. After cooling, dioxin is distilled off under a vacuum created by a water-jet pump, and excess phenoxyethylene is distilled off under high vacuum. The residue is shaken with a solution of tartaric acid and methylchloride, bring the acidic phase to alkaline with concentrated ammonia and extract with methylene chloride. After evaporation of the p the residue is crystallized by means of 0.5 mol of malonic acid from methanol (melting point of hydrogenmalonate 135-137 °). By analogy with example 1, it is obtained by treating the corresponding compounds according to formula (II), where R denotes -CtiCH -Ci, corresponding compounds to formula (111) the following compounds of formula (I) are presented in Table 1. Example 23. A compound 1- (3-chloro-2-methylindol-4-yloxy) -3- (2-phenoxy-ethylamino) -2-propanol is obtained in a manner similar to Example 1 of 5 g of 4- (3-brom-2-hydroxyproxyl) -3-chloro-2-methylindole and 4.3 g of phenoxyethylamine 75 ml of dioxane (m.p. acid malonate 135-137c) EXAMPLE 24 A compound 1- (3-chloro-2-methylindole-4-yloxy) -3 - (2-phenoxy-ethylamino) -2-propanol is obtained in the same manner as in Example 1 of. 6 g of 3-chloro-4- (2-hydroxy-3-mesyloxypropoxy) -2-methylindole and 4.3 g of phenoxyethylamine in 75 ml of dioxane (mp. Acid malonate 135-137c). Example 25. Get connection 1- (3-chlorop-2-methylindoyl-4-ylloxy) -3- (2-phenoxy-ethylamino) -2-propanol as in example 1 of 6 g of 3-chloro-4- (2-hydroxy -3-mesyloxypropoxy) -2-methylindole and 4.3 g of phenoxyethylamine in 75 ml of dioxane (mp. Acidic malonate 135-137). Example 26. Get connection 1- (3-chloro-2-methylindol-4-yloxy) -3- (2-phenoxy-ethylamino) -2-propanol as in example 1 from 7.2 g 3-chloro-4- (2-hydroxy -Z-p-tosyloxypropoxy) -2-methylindole and 4.3g of phenoxyethylamine in 75 ml of dioxane (mp. Acid malonate 135-137 °). Example 27. Get connection 1- (3-chloro-2-methylindol-4-yloxy) -3- (2-phenoxy-ethylamino) -2-propanol as in example 1 of 7.5 g of 4- (3-benzylsulfonyl-2 -hydroxypropoxy) -3-chloro-2 -methylindole and 4.3 g of phenoxyethylamine in 75 ml of dioxane (T.L. acidic malonate 135-137). The compound of formula (I) or their physiologically tolerable salts have interesting pharmacological properties, and therefore they can be used as antihypertensive agents, for example, in the treatment of high pressure.
    Table
    Osh-CHiCHi-xQ OCHj
    SNS
    I / G -C-CHi 5 JboH
    sn.
    SNS
    -cn-VCN
    SNS
    CHi
    .-nW / L
    -С-СНг-0-ССШН ,, СНз
    CHzCHz-OHQ) CH3 C-CHG-0-O-OH
    SNS
    , SNSF
    I SNS
    SNS
    / VOH
    15 - -C-CHi
    SNS
    , SNSF
    // V,
     ouznz
    GHL 88
    CN (foaming)
    ф 172-175 °
    CN
    b 198-200 °
    HCQ-NHj
    HCONHzF 209-212
    .,about
    HCONH2ghl 111-113
    H SOKNGF 170-173 °
    ghl ab 94 (foaming)
    f 157-160
    ф 236-238 °;
    СНг СООСНгСНз ф 241-243 °
    | 0
    b 129-13G
    CHj C1
    权利要求:
    Claims (1)
    [1]
    The claims of the invention A method for producing indole derivatives of the general formula
    SI b - in free form; f bis (basic) fumarate; ghl - hydrochloride; gf - hydrOgenfumarate; GMI hydrogen maleate.
    or their salts, characterized in that the compound of the general formula where where R is a group A alkylene with 2-5 C,. breeds;
    Rj
    A connection or kis40 "1 * 1
    R, '9 is hydrogen, an oxy or alkoxy group with 1-4 C, a cyano or carbamoyl group;
    hydrogen, or if R „is alkoxy with 1-4 C, it also means an alkoxy group with 1-4 C;
    hydrogen or methyl; cyano, CONRaRB, COORc or CH a 0Ke, / where Ra-Re is independently hydrogen or alkyl from 1-4 C; or R, methyl and R ^ are halogen or
    - halogen, a R ^ is methyl, or under the condition that a) X is at least two carbon atoms away from the nitrogen atom of a 3-amino-2-hydroxypropoxy chain; b) if X is a bond, then R > ~ is not hydrogen ^ c) if R & is a cyano group, R is also an alkyl with 3-7 C,
    VNIIPI Order 5200/89 where R. and Rj - have the above ’meanings;
    R x is a group which, when reacted with an amine, gives a 2-amino-1-hydroxyethyl group, for example, a group <^ Na. / CH th or a reactive derivative of this group; subjected to interaction with an amine of the General formula RNH ^, where R - has the above meanings; and the target product is isolated in free form or in the form of a salt.
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    引用文献:
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    FR1547056A|1966-12-13|1968-11-22|Sandoz Sa|Indole derivatives and their preparation|
    FR2019185B1|1968-09-30|1973-01-12|Sandoz Sa|
    US3699123A|1970-03-24|1972-10-17|Sandoz Ltd|4- indole derivatives|
    US4076829A|1974-11-16|1978-02-28|Boehringer Mannheim Gmbh|Aminopropanol compounds and compositions for the treatment of cardiac and circulatory diseases|
    DE2508251C2|1975-02-26|1983-12-29|Boehringer Mannheim Gmbh, 6800 Mannheim|Derivatives of indole, processes for their preparation and medicaments containing them|
    DE2633839A1|1975-08-07|1977-02-24|Sandoz Ag|NEW 4-AMINOPROPOXYINDOLDE DERIVATIVES, THEIR PRODUCTION AND USE|
    DE2635209C2|1975-08-15|1983-01-27|Sandoz-Patent-GmbH, 7850 Lörrach|4- -2-methylindole, its -enantiomer, their acid addition salts, processes for their preparation and medicaments containing these compounds|DE2905877A1|1979-02-16|1980-08-28|Boehringer Mannheim Gmbh|NEW AMINOPROPANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS|
    EP0025111B1|1979-08-10|1984-07-25|Sandoz Ag|3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them|
    DE3030047A1|1980-08-08|1982-03-11|Boehringer Mannheim Gmbh, 6800 Mannheim|NEW AMINOPROPANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    CH906577|1977-07-21|
    CH907377|1977-07-21|
    CH907077|1977-07-21|
    CH907777A|CH632246A5|1977-07-21|1977-07-21|Process for preparing novel 3-aminopropoxyindoles|
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